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Xanthii Fructus inhibits allergic response in the ovalbumin-sensitized mouse allergic rhinitis model
| Content Provider | Scilit |
|---|---|
| Author | Sohn, Youngjoo Gwak, Nam-Gil Kim, Eun-Young Lee, Bina Kim, Jae-Hyun Im, Yong-Seok Lee, Ka-Yeon Kim, Ho-Seok Cho, Hyun-Joo Jung, Hyuk-Sang Jun-Kum, Chang |
| Copyright Year | 2015 |
| Abstract | Background: Xanthii Fructus (XF) is widely used in traditional anti-bacterial and anti-inflammatory Asian medicine. Allergic rhinitis is a common inflammatory disease characterized by markedly increased levels of anti-inflammatory factors and the recruitment of inflammatory cells into the nasal mucosa. We investigated the effects of XF in the allergen-induced rhinitis model. Materials and Methods: Following ovalbumin (OVA)/alum intraperitoneal injection on days 0, 7 and 14, the BALB/c mice (albino, laboratory-bred strain of the house mice) were challenged intranasally with OVA for 10 days a week after the last sensitization. The number of sneezes was recorded for 10 days; additionally, the levels of cytokines, histamine, immunoglobulin E (IgE) and OVA-specific serum IgE were estimated. Eosinophil infiltration, thickness of nasal mucosa and expression of caspase-1 were determined by immunohistochemistry. We also evaluated the effect of XF on the phosphorylation of nuclear factor kappa-B (NF-κB) and inhibitor of nuclear factor kappa B-alpha (IκB-α) in human mast cell-1 (HMC-1), by Western blotting. Results: The administration of XF significantly decreased sneezing and the serum levels of histamine, IgE, OVA-specific IgE, and cytokines such as tumor necrosis factor-alpha (TNF-α), interleukine-1 beta (IL-1β), IL-5, IL-6, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2). XF inhibited the changes in thickness of the nasal septum, influx of eosinophils and expression of capase-1. In addition, XF inhibited the phosphorylation of IκB-α and NF-κB in phorbol-myristate-acetate plus calcium ionophore A23187 (A23187) stimulated HMC-1. Conclusion: This study suggests that XF acts a potent anti-allergic drug which alleviates the allergic responses in ovalbumin-sensitized mouse allergic rhinitis model. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653347/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=352;epage=361;aulast=Gwak;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.166058 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 44 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Allergic Rhinitis Nasal Symptom Immunoglobulin E Histamine Nuclear Factor Kappa-b Xanthii Fructus Pharmacognosy Magazine, Volume 11, Issue 44 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
