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Neuroprotective compounds of Tilia amurensis
| Content Provider | Scilit |
|---|---|
| Author | Ma, Choong Je Lee, Bohyung Weon, Jin Bae Eom, Min Rye Jung, Youn Sik |
| Copyright Year | 2015 |
| Abstract | Background: Tilia amurensis (Tiliacese) has been used for anti-tumor and anti-inflammatory in Korea, China, and Japan. Objective: In this study, we isolated five compounds from T. amurensis and determined whether protected neuronal cells against glutamate-induced oxidative stress in HT22 cells. Materials and Methods: Compounds were isolated using chromatographic techniques including silica gel, Sephadex LH-20 open column and high performance liquid chromatography analysis, and evaluated neuroprotective effect in HT22 cells by 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Results: β-D-fructofuranosyl α-D-glucopyranoside (1), (-)-epicatechin (2), nudiposide (3), lyoniside (4), and scopoletin (5) were isolated by bioactivity-guided fractionation from the ethyl acetate fraction of T. amurensis. Among them, (-)-epicatechin, nudiposide, lyoniside, and scopoletin had significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. Conclusion: These results demonstrated that compound two, three, four, and five have a pronounced protective effect against glutamate-induced neurotoxicity in HT22 cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653341/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=303;epage=307;aulast=Lee;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.166065 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 44 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2015-01-01 |
| Access Restriction | Open |
| Subject Keyword | Medicinal Chemistry Toxicology Bioactivity Compounds Glutamate Excitotoxicity Ht22 Cell Neuroprotection Tilia Amurensis Pharmacognosy Magazine, Volume 11, Issue 44 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
