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A direct protein kinase B-targeted anti inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris
| Content Provider | Scilit |
|---|---|
| Author | Cho, Jae Youl Noh, Hyung Jun Yoon, Ju Young Kim, Ji Hye Baek, Kwang-Soo Kim, Geum Soog Lee, Seung Eun Lee, Dae Young Choi, Je Hun Kim, Seung Yu Park, Hyun Bong Sung, Gi-Ho Lee, Kang Ro |
| Copyright Year | 2015 |
| Abstract | Background: Cordyceps militaris is one of well-known medicinal mushrooms with anti-inflammatory, anti-cancer, anti-diabetic, and anti-obesity activities. Objective: The objective of the following study is to isolate chemical components from the ethanol extract (Cm-EE) from Cordyceps militaris and to evaluate their anti-inflammatory activities. Materials and Methods: Column chromatographic separation was performed and anti-inflammatory roles of these compounds were also examined by using NO production and protein kinase B (AKT) activity assays. Results: From Cm-EE, 13 constituents, including trehalose (1), cordycepin (2), 6-hydroxyethyladenosine (3), nicotinic amide (4), butyric acid (5), β-dimorphecolic acid (6), α-dimorphecolic acid (7), palmitic acid (8), linoleic acid (9), cordycepeptide A (10), 4-(2-hydroxy-3-((9E,12E)-octadeca-9,12-dienoyloxy)propoxy)-2-(trimethylammonio)butanoate (11), 4-(2-hydroxy-3-(palmitoyloxy)propoxy)-2-(trimethylammonio)butanoate (12), and linoleic acid methyl ester (13) were isolated. Of these components, compound 2 displayed a significant inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW264.7 cells. Furthermore, this compound strongly and directly suppressed the kinase activity of AKT, an essential signalling enzyme in LPS-induced NO production, by interacting with its ATP binding site. Conclusion: C. militaris could have anti-inflammatory activity mediated by cordycepin-induced suppression of AKT. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522833/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=43;spage=477;epage=485;aulast=Yoon;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.160454 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 43 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Anti-inflammatory Activity Cordycepin Cordyceps Militaris (clavicipitaceae) Phytochemical Study Protein Kinase B Pharmacognosy Magazine, Volume 11, Issue 43 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
