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Comparative studies of selected Calophyllum plants for their anti-inflammatory properties
| Content Provider | Scilit |
|---|---|
| Author | Mah, Siau Hui Teh, Soek Sin Ee, Gwendoline Cheng Lian |
| Copyright Year | 2019 |
| Abstract | Background: Calophyllum (Clusiaceae) plants have been used as traditional medicine for rheumatism, vein problems, hemorrhoids, and gastric ulcers. The traditional uses of this genus prompted us to investigate six Malaysian Calophyllum species which are Calophyllum inophyllum, Calophyllum soulattri, Calophyllum lowii, Calophyllum teysmannii, Calophyllum benjaminum and Calophyllum javanicum for their anti-inflammatory properties. Materials and Methods: The stem bark of six plants was extracted with n-hexane (Hex), ethyl acetate (EA), and methanol (MeOH). The activities of the extracts were evaluated by determining the inhibition of nitric oxide (NO) production by lipopolysaccharide-induced RAW 264.7 cells, as well as protein denaturation. Results and Discussion: The C. lowii extracts showed the most significant activities against NO production with $IC_{50}$values of <40 μg/mL. For the protein denaturation test, C. teysmannii extracts showed the strongest effect with $IC_{50}$values of <100 μg/mL. The results indicated that C. lowii and C. teysmannii are effective in both assays. Besides, the Hex extracts of these Calophyllum plants possess stronger activities than the EA and MeOH extracts. The anti-inflammatory properties are contributed by the secondary metabolites present in the crude extracts, specifically flavonoid, triterpenes, and xanthones. Conclusion: These results confirm the potential of Calophyllum plants to serve as lead agents in preventing inflammation. Abbreviations used: NO: Nitric oxide; spp.: Species; Hex: Hexane; EA: Ethyl acetate; MeOH: Methanol. |
| Related Links | http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=60;spage=135;epage=139;aulast=Mah;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/pm.pm_212_18 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 60 |
| Volume Number | 15 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Calophyllum Inflammation Nitric Oxide Inhibition Phytochemical Protein Denaturation Pharmacognosy Magazine, Volume 15, Issue 60 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
