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Magnetic hyperthermia efficiency $and^{1}$H-NMR relaxation properties of iron oxide/paclitaxel-loaded PLGA nanoparticles
| Content Provider | Scilit |
|---|---|
| Author | Ruggiero, Maria R. Crich, Simonetta Geninatti Sieni, Elisabetta Sgarbossa, Paolo Forzan, Michele Cavallari, Eleonora Stefania, Rachele Dughiero, Fabrizio Aime, Silvio |
| Copyright Year | 2016 |
| Description | Journal: Nanotechnology Magnetic iron oxide nanoparticles (Fe-NPs) can be exploited in biomedicine as agents for magnetic fluid hyperthermia (MFH) treatments and as contrast enhancers in magnetic resonance imaging. New, oleate-covered, iron oxide particles have been prepared either by co-precipitation or thermal decomposition methods and incorporated into poly(lactic-co-glycolic acid) nanoparticles (PLGA-Fe-NPs) to improve their biocompatibility and in vivo stability. Moreover, the PLGA-Fe-NPs have been loaded with paclitaxel to pursue an MFH-triggered drug release. Remarkably, it has been found that the nanoparticle formulations are characterized by peculiar$ ^{1}$H nuclear magnetic relaxation dispersion (NMRD) profiles that directly correlate with their heating potential when exposed to an alternating magnetic field. By prolonging the magnetic field exposure to 30 min, a significant drug release was observed for PLGA-Fe-NPs in the case of the larger-sized magnetic nanoparticles. Furthermore, the immobilization of lipophilic Fe-NPs in PLGA-NPs also made it possible to maintain Néel relaxation as the dominant relaxation contribution in the presence of large iron oxide cores (diameters of 15–20 nm), with the advantage of preserving their efficiency when they are entrapped in the intracellular environment. The results reported herein show that NMRD profiles are a useful tool for anticipating the heating capabilities of Fe-NPs designed for MFH applications. |
| Related Links | http://pdfs.semanticscholar.org/bee3/6b987a9b78a9fc48a94321c693a8ec1efbcb.pdf http://iopscience.iop.org/article/10.1088/0957-4484/27/28/285104/pdf |
| ISSN | 09574484 |
| e-ISSN | 13616528 |
| DOI | 10.1088/0957-4484/27/28/285104 |
| Journal | Nanotechnology |
| Issue Number | 28 |
| Volume Number | 27 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2016-06-06 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering |
