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Dendron based antifouling, MRI and magnetic hyperthermia properties of different shaped iron oxide nanoparticles
| Content Provider | Scilit |
|---|---|
| Author | Cotin, Geoffrey Andujar, Cristinia Blanco Nguyen, Dinh Vu Affolter-Zbaraszczuk, Christine Boutry, Sébastien Boos, Anne Ronot, Pascale Uring-Lambert, B. Choquet, Philippe Zorn, Pierre Emmanuel Mertz, Damien Laurent, Sophie Muller, Robert Nathan Meyer, Florent Felder-Flesch, Delphine Begin-Colin, S. |
| Copyright Year | 2019 |
| Description | Journal: Nanotechnology Owing to the great potential of iron oxide nanoparticles (NPs) for nanomedicine, large efforts are made to better control their magnetic properties and especially their magnetic anisotropy to provide NPs able to combine imaging by MRI and therapy by magnetic hyperthermia. In that context, the design of anisotropic NPs appears as a very promising and efficient strategy. Furthermore, their bioactive coating remains also a challenge as it should provide colloidal stability, biocompatibility, furtivity along with good water diffusion for MRI. By taking advantage of our controlled synthesis method of iron oxide NPs with different shapes (cubic, spherical, octopod and nanoplate), we demonstrate here that the dendron coating, shown previously very suitable for 10 nm sized iron oxide, provided also very good colloidal, MRI and antifouling properties to the anisotropic shaped NPs. These antifouling properties, demonstrated through several experiments and characterizations, are very promising to achieve specific targeting of disease tissues without affecting healthy organs. On the other hand, the magnetic hyperthermia properties were shown to depend on the saturation magnetization and the ability of NPs to self-align, confirming the need of a balance between crystalline and dipolar magnetic anisotropies. |
| Related Links | https://iopscience.iop.org/article/10.1088/1361-6528/ab2998/pdf |
| ISSN | 09574484 |
| e-ISSN | 13616528 |
| DOI | 10.1088/1361-6528/ab2998 |
| Journal | Nanotechnology |
| Issue Number | 37 |
| Volume Number | 30 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2019-06-13 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanotechnology Magnetic Hyperthermia Properties |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering |
