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Glioma diagnostics and biomarkers: an ongoing challenge in the field of medicine and science
| Content Provider | Scilit |
|---|---|
| Author | Hochberg, Fred H. Atai, Nadia A. Gonda, David Hughes, Michael S. Mawejje, Brolin Balaj, Leonora Carter, Robert S. |
| Copyright Year | 2014 |
| Description | Journal: Expert Review of Molecular Diagnostics Glioma is the most common brain tumor. For the more aggressive form, glioblastoma, standard treatment includes surgical resection, irradiation with adjuvant temozolomide and, on recurrence, experimental chemotherapy. However, the survival of patients remains poor. There is a critical need for minimally invasive biomarkers for diagnosis and as measures of response to therapeutic interventions. Glioma shed extracellular vesicles (EVs), which invade the surrounding tissue and circulate within both the cerebrospinal fluid and the systemic circulation. These tumor-derived EVs and their content serve as an attractive source of biomarkers. In this review, we discuss the current state of the art of biomarkers for glioma with emphasis on their EV derivation. |
| Related Links | http://europepmc.org/articles/pmc5451266?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451266/pdf |
| Ending Page | 452 |
| Page Count | 14 |
| Starting Page | 439 |
| ISSN | 14737159 |
| e-ISSN | 17448352 |
| DOI | 10.1586/14737159.2014.905202 |
| Journal | Expert Review of Molecular Diagnostics |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Expert Review of Molecular Diagnostics Medical Laboratory Technology Microvesicles Extracellular Vesicles |
| Content Type | Text |
| Subject | Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine |
