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The potential of tumor-derived exosomes for noninvasive cancer monitoring: an update
| Content Provider | Scilit |
|---|---|
| Author | Whiteside, Theresa L. |
| Copyright Year | 2018 |
| Description | Journal: Expert Review of Molecular Diagnostics Introduction: Liquid biopsy platforms are being actively developed in the biomarker field. Extracellular vesicles (EVs), especially the tumor-derived exosome subsets of EVs, represent a platform that allows for molecular and genetic profiling of parent tumor cells. Tumor-derived exosomes (TEX) are ubiquitous in body fluids of cancer patients and are promising clinically-relevant surrogates of cancer cells. Areas covered: Isolation from body fluids of cancer patients and subsetting of exosomes based on immunoaffinity capture offers a means of evaluating proteins, lipids, nucleic acids and other molecular contents that are a characteristic of TEX and exosomes produced by reprogrammed normal cells. The same liquid biopsy can inform about the status of a tumor and simultaneously evaluate the competency of immune cells to mediate anti-tumor activities. Expert Commentary: TEX and reprogrammed non-TEX isolated from plasma of cancer patients have the potential to become non-invasive biomarkers of cancer diagnosis, prognosis and response to therapies. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506389/pdf |
| Ending Page | 1040 |
| Page Count | 12 |
| Starting Page | 1029 |
| ISSN | 14737159 |
| e-ISSN | 17448352 |
| DOI | 10.1080/14737159.2018.1544494 |
| Journal | Expert Review of Molecular Diagnostics |
| Issue Number | 12 |
| Volume Number | 18 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-11-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Expert Review of Molecular Diagnostics Medical Laboratory Technology Extracellular Vesicles Tumor-derived Exosomes Non-invasive Biomarkers Immune Capture Molecular Profiling Protein Cargo |
| Content Type | Text |
| Subject | Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine |
