NDLI: Circulating microRNAs as diagnostic biomarkers for pancreatic cancer.

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Circulating microRNAs as diagnostic biomarkers for pancreatic cancer.

Content Provider	Scilit
Author	Large, Tessa Y. S. Le Meijer, Laura L. Prado, Mireia Mato Kazemier, Geert Frampton, Adam E. Giovannetti, Elisa
Copyright Year	2015
Description	Journal: Expert Review of Molecular Diagnostics There is an urgent need for novel and reliable biomarkers for the diagnosis and prognostication of pancreatic ductal adenocarcinoma (PDAC). Circulating microRNAs (miRNAs) have been extensively profiled in PDAC blood samples, but few studies have performed adequate validation of candidate markers. The evaluated study by Xu et al. investigated pre-operative plasma miRNAs from PDAC patients over three phases and three surgical centers. They revealed miR-486-5p and miR-938 were able to discriminate PDAC patients from healthy controls and those with chronic pancreatitis. The diagnostic ability of miR-486-5p for identifying PDAC from healthy controls was comparable to that of CA 19-9. This study provides further evidence for the use of blood-based miRNAs as diagnostic biomarkers in PDAC. However, as these have not been identified in previous studies these require further validation and methodology needs to be standardized if these are ever to be used in the clinic.
Related Links	http://www.tandfonline.com/doi/pdf/10.1586/14737159.2015.1112273?needAccess=true
ISSN	14737159
e-ISSN	17448352
DOI	10.1586/14737159.2015.1112273
Journal	Expert Review of Molecular Diagnostics
Issue Number	12
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-11-07
Access Restriction	Open
Subject Keyword	Journal: Expert Review of Molecular Diagnostics Medical Laboratory Technology Chronic Pancreatitis Pancreatic Ductal Adenocarcinoma
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine

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