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Myeloid neoplasms after breast cancer: “therapy-related” not an independent poor prognostic factor
| Content Provider | Scilit |
|---|---|
| Author | O’Brien, Susan Chen, Yiming Estrov, Zeev Pierce, Sherry Qiao, Wei Borthakur, Gautam Ravandi, Farhad Kadia, Tapan Brandt, Mark Jabbour, Elias Garcia-Manero, Guillermo Cortes, Jorge Beran, Miloslav |
| Copyright Year | 2014 |
| Description | Journal: Leukemia & Lymphoma Two hundred and thirty-five consecutive patients presenting to a single center with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after breast cancer treatment were compared with matched patients with de novo AML or MDS. There was no significant difference in median overall survival (OS) times between patients with therapy-related AML and those with de novo AML (8.7 months vs.10.2 months; p = 0.17). Patients with therapy-related MDS had slightly lower median baseline platelet counts and a higher frequency of poor cytogenetics than those with de novo MDS, but the two groups had similar OS times (13.6 months vs. 18.9 months; p = 0.06). Multivariate analysis revealed that cytogenetic risk, baseline white blood cell count, age and performance status were predictive for OS time in AML and that cytogenetic risk and performance status were predictive for OS time in MDS. Having therapy-related disease is not an independent risk factor in patients with myeloid neoplasms and with a history of breast cancer. Clinical trials should be designed to serve both populations. |
| Related Links | http://europepmc.org/articles/pmc4326620?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326620/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2014.946023 |
| Ending Page | 1019 |
| Page Count | 8 |
| Starting Page | 1012 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2014.946023 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 4 |
| Volume Number | 56 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Medical Laboratory Technology Myeloid Leukemias and Dysplasias Chemotherapeutic Approaches Prognostication |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
