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Dose-reduced combination of mitoxantrone, etoposide, and cytarabine (miniMEC) for relapsed and refractory acute leukemia
| Content Provider | Scilit |
|---|---|
| Author | Yamamoto, Chihiro Ito, Shoko Mashima, Kiyomi Umino, Kento Minakata, Daisuke Yamasaki, Ryoko Kawasaki, Yasufumi Sugimoto, Miyuki Nakano, Hirofumi Ashizawa, Masahiro Okazuka, Kiyoshi Hatano, Kaoru Sato, Kazuya Oh, Iekuni Fujiwara, Shin-Ichiro Ohmine, Ken Suzuki, Takahiro Muroi, Kazuo Kanda, Yoshinobu |
| Copyright Year | 2016 |
| Description | The combination of mitoxantrone (MIT), etoposide (ETP), and cytarabine (Ara-C) (MEC) is a frequently used salvage therapy for acute leukemia, but has been associated with severe myelosuppression. Therefore, we investigated the miniMEC regimen with reduced doses of AraC and MIT. Thirteen ALL and 44 AML patients, all relapsed or refractory, received miniMEC, which consisted of MIT at 8 $mg/m^{2}$ for 3 d, ETP at 100 $mg/m^{2}$ for 5 d, and Ara-C at 100 $mg/m^{2}$ infused over 24 h for 7 d. CR + CRi was achieved in eight ALL patients (61.5%) and 16 AML patients (36.4%). Median duration of neutropenia was 30 d (range, 1–50). Thirty-one patients (54.4%) subsequently received allogeneic stem cell transplantation (SCT), and overall survival was significantly improved in this group (median OS 161 versus 481 d, p = 0.006). We concluded that miniMEC is a safe and effective bridging therapy to SCT. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428194.2016.1153087 |
| Ending Page | 2547 |
| Page Count | 7 |
| Starting Page | 2541 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2016.1153087 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 11 |
| Volume Number | 57 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Chemotherapeutic Approaches Lymphoid Leukemia Myeloid Leukemias and Dysplasias |
| Content Type | Text |
| Subject | Hematology Cancer Research Oncology |
