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Influence of obesity on efficacy and toxicity of induction chemotherapy in patients with newly diagnosed acute myeloid leukemia
| Content Provider | Scilit |
|---|---|
| Author | Lin, Andrew Othus, Megan McQuary, Amy Chi, Mary Estey, Elihu |
| Copyright Year | 2012 |
| Description | Increased body mass index (BMI) is associated with increased risk of treatment-related complications and inferior overall survival in patients with acute myeloid leukemia (AML). We retrospectively evaluated the association between percentage of ideal body weight (IBW) and complete remission (CR) among 63 newly diagnosed, previously untreated patients with AML. The median percentage of ideal body weight was 121% (range 86–246%). Thirty-three percent of patients were obese (≥ 130% IBW). In multivariate analysis, obesity was not associated with CR (odds ratio [OR] = 0.97, p = 0.88), overall survival (hazard ratio = 0.48, p = 0.52), platelet recovery by 30 days (OR = 1.14, p = 0.52) or neutrophil recovery by 30 days (OR = 1.12, p = 0.60). Obesity was also not associated with any differences in non-hematologic toxicity. CR rates were not significantly different comparing patients not dose-adjusted to patients with obesity-related adjustments (CR = 86% vs. 67%, p = 0.55). Empiric dose reductions based on obesity did not result in significantly different CR rates. |
| Related Links | http://europepmc.org/articles/pmc4451200?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451200/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2012.717278 |
| Ending Page | 546 |
| Page Count | 6 |
| Starting Page | 541 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2012.717278 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 3 |
| Volume Number | 54 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-08-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Myeloid Leukemias and Dysplasias Chemotherapeutic Approaches Pharmacotherapeutics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
