NDLI: Acute Leukemia Complicating Bone Marrow Hypoplasia in an Adult with Shwachman's Syndrome

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Acute Leukemia Complicating Bone Marrow Hypoplasia in an Adult with Shwachman's Syndrome

Content Provider	Scilit
Author	Seymour, J. F. Escudier, S. M.
Copyright Year	1993
Description	Journal: Leukemia & Lymphoma Shwachman's syndrome is a rare congenital disorder associated with neutropenia and exocrine pancreatic insufficiency. We describe the development of acute myeloid leukemia in a 38-year-old patient with Shwachman's syndrome following three years of pancytopenia. After chemotherapy the leukemic clone was eradicated, however, the patient's bone-marrow hypoplasia persisted beyond 180 days with neutropenia that responded to administration of granulocyte colony-stimulating factor. Despite the patient's low erythropoietin levels, administration of erythropoietin did not improve his hemoglobin. We review previously reported cases of leukemia complicating Shwachman's syndrome with emphasis on the persistent risk of complications in patients with congenital bone-marrow failure syndromes.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/10428199309059581
Ending Page	135
Page Count	5
Starting Page	131
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428199309059581
Journal	Leukemia & Lymphoma
Issue Number	1-2
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	1993-01-01
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Anesthesiology Shwachman's Syndrome Acute Leukemia Aplastic Anemia
Content Type	Text
Subject	Hematology Cancer Research Oncology

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