NDLI: Hematogones are markedly reduced in pediatric acquired aplastic anemia: multiparametric flow cytometric analysis

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Hematogones are markedly reduced in pediatric acquired aplastic anemia: multiparametric flow cytometric analysis

Content Provider	Scilit
Author	Sevilla, Deborah W. Emmons, Foxwell N. Colovai, Adriana I. Beaubier, Nike T. Baker, Courtney Bhatia, Monica Bhagat, Govind Alobeid, Bachir
Copyright Year	2009
Description	Acquired aplastic anemia (AA) and myelodysplastic syndromes (MDS) are bone marrow (BM) failure syndromes with overlapping clinical features, and at least a subset appears to share common pathophysiologic mechanisms. Recent studies of MDS have shown down-regulation of genes involved in B-cell development and decreased B-cell precursors (hematogones). We explored the possibility that AA, similar to MDS, might also be associated with defects in development of lymphoid cells, especially B-cells, by using flow cytometry to assess the presence of hematogones and mature lymphocytes in BM samples from 25 children with AA and 41 age-matched controls. We observed that the percentage of total and early (stage I) hematogones were significantly decreased in AA compared to controls, and they returned to normal numbers after hematopoietic stem-cell transplant. This demonstrates early B-cell lineage involvement in AA, similar to recent findings in MDS. Our findings suggest dysfunction of an early multilineage progenitor in the pathogenesis of AA.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/10428190903156737
Ending Page	1957
Page Count	7
Starting Page	1951
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428190903156737
Journal	Leukemia & Lymphoma
Issue Number	12
Volume Number	50
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-09-30
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Pediatrics and Child Health Hematogones Children Hematopoietic Bone Marrow Anemia Flow Mds Aplastic
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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