NDLI: Acute Megakaryoblastic Leukemia: Importance of Bone Marrow Biopsy in Diagnosis

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Acute Megakaryoblastic Leukemia: Importance of Bone Marrow Biopsy in Diagnosis

Content Provider	Scilit
Author	Lorand-Metze, Irene Vassallo, José Aoki, Regina Yoko Souza, Carmino Antonio De
Copyright Year	1991
Description	Five cases of megakaryoblastic leukemia, presenting as “de novo” acute leukemias are reported. They represented 7.2% of all cases of adult acute non-lymphoblastic leukemias (ANLL) seen in our Hematology Service during the past 30 months. These cases showed features of predominantly blast proliferation with a marked increase of reticulin fibres in the bone marrow. One case had features of acute leukemia with trilineage myelodysplasia and one had a more chronic evolution with splenomegaly initially resembling a myeloproliferative syndrome. In all cases, the definitive diagnosis was made on bone marrow histology as cytology was poor and the blast cells were positive for factor VIII with the immunoperoxidase technique. The importance of bone marrow histology is emphasized.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/10428199109107060
Ending Page	79
Page Count	5
Starting Page	75
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428199109107060
Journal	Leukemia & Lymphoma
Issue Number	1
Volume Number	4
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Leukemia & Lymphoma Pathology Leukemia Megakaryoblastic Leukemia Bone Marrow Biopsy
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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