NDLI: Poly(Ethylene Glycol)-Coated Biodegradable Nanospheres for Intravenous Drug Administration

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Poly(Ethylene Glycol)-Coated Biodegradable Nanospheres for Intravenous Drug Administration

Content Provider	Scilit
Author	Gref, Ruxandra Minamitake, Yoshiharu Peracchia, Maria Teresa Langer, Robert
Copyright Year	2020
Description	This chapter describes an approach to creating degradable polymeric nanospheres that, to a large extent, display the desired features of long-circulating drug carriers. The development of injectable drug-loaded carriers with blood circulation times long enough to continuously deliver drugs, imaging agents, or other molecules, to specific sites in the body has been a major challenge. The efficacy of Poly(ethylene glycol) (PEG)-coated nanoparticles in avoiding opsonization can be determined by incubating samples with plasma proteins, then measuring the nature and the amount of the adsorbed proteins. One of the goals of PEG-coated nanospheres is to achieve drug-loaded carriers, able to liberate the active compound in a controlled manner directly into the bloodstream. Drug release and polymer degradation are two interconnected phenomena. Poly(ethylene glycol)-coated nanospheres are a promising new system that has potential for intravenous drug administration. The nanospheres' hydrodynamic diameter and size distribution can be measured by quasi-elastic light scattering, also called photon correlation spectroscopy. Book Name: Microparticulate Systems for the Delivery of Proteins and Vaccines
Related Links	https://content.taylorfrancis.com/books/download?dac=C2010-0-29490-7&isbn=9781003067542&doi=10.1201/9781003067542-9&format=pdf
Ending Page	306
Page Count	28
Starting Page	279
DOI	10.1201/9781003067542-9
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-07-24
Access Restriction	Open
Subject Keyword	Book Name: Microparticulate Systems for the Delivery of Proteins and Vaccines Biomedical Engineering Polymer Degradation
Content Type	Text
Resource Type	Chapter

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