NDLI: Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

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Fabrication of biodegradable PEG–PLA nanospheres for solubility, stabilization, and delivery of curcumin

Content Provider	Scilit
Author	Liang, Hongying Friedman, Joel M. Nacharaju, Parimala
Copyright Year	2016
Description	Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)–poly (lactic acid) (PEG–PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.
Related Links	https://www.tandfonline.com/doi/pdf/10.3109/21691401.2016.1146736?needAccess=true https://www.tandfonline.com/doi/pdf/10.3109/21691401.2016.1146736
Ending Page	304
Page Count	8
Starting Page	297
ISSN	21691401
e-ISSN	2169141X
DOI	10.3109/21691401.2016.1146736
Journal	Artificial cells, nanomedicine, and biotechnology
Issue Number	2
Volume Number	45
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-02-17
Access Restriction	Open
Subject Keyword	Biomaterials Curcumin Drug Delivery Nanospheres Poly(ethylene Glycol)–poly(lactic Acid)
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering Biotechnology Pharmaceutical Science

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