NDLI: Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway

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Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway

Content Provider	Scilit
Author	Jiang, Wenjie Chen, Yuan Song, Xing Shao, Yingjie Ning, Zhonghua Gu, Wendong
Copyright Year	2019
Description	Journal: OncoTargets and therapy Background: In the present study, we aimed to investigate the effect of proviral integration site for moloney murine leukemia virus-1 (Pim-1) inhibitor (SMI-4a) on the progression of non-small cell lung cancer (NSCLC). Materials and methods: The effects of SMI-4a on proliferation, apoptosis, and cell cycle of NSCLC cells were examined by in vitro experiments using human NSCLC cell lines (A549 and Ltep-a-2). The pathway regulated by SMI-4a was detected using Western blot. Furthermore, we performed in vivo experiments to assess the effects of SMI-4a on tumor growth using mouse models with NSCLC. Results: Our data demonstrated that SMI-4a could inhibit the proliferation of A549 and Ltep-a-2 cells markedly in a dose-dependent manner (P<0.05). Treatment with 80 μmol/L of SMI-4a for 48 h significantly induced the apoptosis rate of NSCLC cells (P<0.05), and blocked the cell cycle of NSCLC cells in G2/M phase (P<0.05). The phosphorylation levels of PI3K, AKT, and mTOR in NSCLC cells were significantly downregulated by SMI-4a (P<0.05). Result from in vivo experiments demonstrated that SMI-4a could suppress the tumor growth in mouse models with NSCLC (P<0.05). Conclusions: SMI-4a suppresses the progression of NSCLC by blocking the PI3K/AKT/mTOR pathway.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497832/pdf https://www.dovepress.com/getfile.php?fileID=49269
Ending Page	3050
Page Count	8
Starting Page	3043
ISSN	11786930
DOI	10.2147/ott.s203142
Journal	OncoTargets and therapy
Volume Number	ume 12
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-04-01
Access Restriction	Open
Subject Keyword	Journal: OncoTargets and therapy Tumor Progression
Content Type	Text
Subject	Pharmacology (medical) Oncology

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