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Drug Release from Semi-Solid Matrix Systems in Hard Capsules
| Content Provider | Scilit |
|---|---|
| Author | Mathis, C. Heimendinger, J. |
| Copyright Year | 1989 |
| Description | Journal: Drug Development and Industrial Pharmacy The authors have prepared hard capsules containing semisolid matrix systems with fatty excipients and acetylsalicylic acid (ASA) in order to decrease the dissolution rate of this active substance. With excipients like Gélucires and Simulsols, they obtained matrix systems easy to prepare and having a good stability, at least until 37°C. These systems release in vitro acetylsalicylic acid in about 8 hours; but administered p.o. to man they release ASA too rapidly in less then 4 hours |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639048909052538 |
| Ending Page | 2417 |
| Page Count | 11 |
| Starting Page | 2407 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639048909052538 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 14-16 |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1989-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Anesthesiology Pharmacology and Pharmacy Drug Release Solid Matrix Hard Capsules Matrix Systems |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |