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The preparation of prolonged action formulations in the form of semi solid matrix into hard gelatin capsules of oxprenolol II. Thixocap Method
| Content Provider | Scilit |
|---|---|
| Author | Baykara, Tamer Yüksel, Nilüfer |
| Copyright Year | 1992 |
| Description | Journal: Drug Development and Industrial Pharmacy In this study, it was aimed to obtain prolonged release preparations in the form o f semisolid matrices (SSM) o f Oxprenolol as a model drug into mixtures possessing thixotropic property by filling in the hard gelatin capsules. The results of this study showed that the formulation, prepared with liquid paraffin and Cutina HR, gave kinetic values close to that of the polymeric matrix preparation of Oxprenolol HCl used for comparison. However, in the thixotropic formulations, prepared with Isopropyl Myristate and Isopropyl Palmitate by adding Arerosil 200, the drug release was slow, there fore the release in expected period of time and level can be ensured by.adding different. proportions of hydrophilic substances forming channels in the mass without damaging thixotropic structure. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049209043696 |
| Ending Page | 243 |
| Page Count | 11 |
| Starting Page | 233 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049209043696 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 2 |
| Volume Number | 18 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1992-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Prolonged Action Solid Matrix Hard Gelatin Oxprenolol Ii Thixocap Method Action Formulations Gelatin Capsules |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
