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Formation of Sustained Release Wax Matrices Within Hard Gelatin Capsules in a Fluidized Bed
| Content Provider | Scilit |
|---|---|
| Author | Bodmeier, Roland Paeratakul, Ornlaksana Chen, Huagang Zhang, Weiming |
| Copyright Year | 1990 |
| Description | Sustained release wax matrices were formed within hard gelatin capsules during fluidization in a hot air stream. The capsules were filled with drug (propranolol HC1 or dieophylline) – wax (Precirol ATO-5 or Gelucire 50/13) powder blends and suspended in a fluidized bed to induce fusion of the wax. Upon cooling, wax matrices with embedded drug were formed in the ends of die capsules. The use of blends of waxes with different HLB values allowed good control over the drug release pattern. The drug release from the matrices was independent of the pH of the dissolution medium. Differential scanning calorimetry was used to study the physical state of the drugs in the matrices. Propranolol HC1 was insoluble and completely dispersed in the wax matrix while theophylline was partially dissolved in the wax. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049009074380 |
| Ending Page | 1519 |
| Page Count | 15 |
| Starting Page | 1505 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049009074380 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 9 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1990-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Legal Medicine Fluidized Bed Hard Gelatin Wax Matrices Release Wax Gelatin Capsules Sustained Release |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
