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Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Yujia Zhang, Nan Song, Hui Li, He Wen, Jin Tan, Xiaochuan Zheng, Wensheng |
| Copyright Year | 2019 |
| Description | Journal: Drug delivery Gout is a kind of joint disease characterized by the accumulation of monosodium urate (MSU) crystals in the joint and its surrounding tissue, causing persistent hyperuricemia. Colchicine is the first choice of treatment for acute gout attacks. Due to strong toxicity of colchicines oral tablets, there are high fluctuations of blood drug concentration and serious irritation of gastrointestinal tract, and hence a transdermal preparation can help to slow down the blood drug concentration, reduce the frequency of drug taking, and improve the patients' compliance of the drug. The ethosome is a lipid carrier with high concentration of ethanol and has been proved to promote the penetration of drugs into the skin. Borneol (BO) is an excellent penetration enhancer in Chinese medicine, which can promote the entry of drugs into the skin. This paper prepared the borneol-physically-modified colchicine ethosome (COL-bpES) and used the prepared borneol-dioleoyl phosphoethanloamine (BO-DOPE) to prepare borneol-chemically-modified colchicine ethosome (COL-bcES). Compared to the free colchicine aqueous solution (free COL) and normal colchicine ethosome (COL-ES), the borneol-modified colchicine ethosome (COL-bES) demonstrated better drug penetration effect, while the particle size of the COL-bcES was lower than that of the COL-bpES. Toxicity, in vitro diffusion, pharmacokinetics and pharmacodynamics are superior to those of COL-bpES, providing a better delivery system for the treatment of small molecule inflammatory drugs. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/10717544.2018.1559258?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374970/pdf |
| Ending Page | 77 |
| Page Count | 8 |
| Starting Page | 70 |
| ISSN | 10717544 |
| e-ISSN | 15210464 |
| DOI | 10.1080/10717544.2018.1559258 |
| Journal | Drug delivery |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug delivery Pharmacology and Pharmacy Transdermal Delivery Borneol-chemically-modified Ethosome Borneol-physically-modified Ethosome |
| Content Type | Text |
| Subject | Medicine Pharmaceutical Science |
