Loading...
Please wait, while we are loading the content...
Similar Documents
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease
| Content Provider | Scilit |
|---|---|
| Author | Tang, Shengnan Wang, Aiping Yan, Xiuju Chu, Liuxiang Yang, Xiucheng Song, Yina Sun, Kaoxiang Yu, Xin Liu, Rongxia Wu, Zimei Xue, Peng |
| Copyright Year | 2019 |
| Description | Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson's disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. In vitro cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. In vivo pharmacokinetic studies indicated that $AUC_{0–12 h}$ in the rat brain for dopamine Lf-BNPs was significantly higher (p < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson's disease. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/10717544.2019.1636420?needAccess=true |
| Ending Page | 707 |
| Page Count | 8 |
| Starting Page | 700 |
| ISSN | 10717544 |
| e-ISSN | 15210464 |
| DOI | 10.1080/10717544.2019.1636420 |
| Journal | Drug delivery |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Delivery Biomaterials Pharmacology and Pharmacy Dopamine Lactoferrin Borneol Nose-to-brain Targeted Nanoparticles Parkinson's Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmaceutical Science |
