NDLI: Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

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Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation

Content Provider	Scilit
Author	Abdulbaqi, Ibrahim M. Darwis, Yusrida Assi, Reem Abou Khan, Nurzalina Abdul Karim
Copyright Year	2018
Description	Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation Ibrahim M Abdulbaqi, Yusrida Darwis, Reem Abou Assi, Nurzalina Abdul Karim Khan School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia Introduction: Colchicine is used for the treatment of gout, pseudo-gout, familial Mediterranean fever, and many other illnesses. Its oral administration is associated with poor bioavailability and severe gastrointestinal side effects. The drug is also known to have a low therapeutic index. Thus to overcome these drawbacks, the transdermal delivery of colchicine was investigated using transethosomal gels as potential carriers.Methods: Colchicine-loaded transethosomes (TEs) were prepared by the cold method and statistically optimized using three sets of 24 factorial design experiments. The optimized formulations were incorporated into Carbopol 940Â® gel base. The prepared colchicine-loaded transethosomal gels were further characterized for vesicular size, dispersity, zeta potential, drug content, pH, viscosity, yield, rheological behavior, and ex vivo skin permeation through Sprague Dawley ratsâ
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898596/pdf https://www.dovepress.com/getfile.php?fileID=41404
Ending Page	813
Page Count	19
Starting Page	795
e-ISSN	11778881
DOI	10.2147/dddt.s158018
Journal	Drug design, development and therapy
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-04-01
Access Restriction	Open
Subject Keyword	Journal: Drug Design, Development and Therapy Pharmacology and Pharmacy Transethosomes Ethosomal Nanocarriers Colchicine Factorial Design Skin Permeation Rheology
Content Type	Text
Resource Type	Article

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