NDLI: Influence of dispersion method on particle size and dissolution of grisgofulvin-silicon dioxide tripurations

Please wait, while we are loading the content...

Influence of dispersion method on particle size and dissolution of grisgofulvin-silicon dioxide tripurations

Content Provider	Scilit
Author	Abdallah, H. Y. Khalafallah, N. Khalil, Said A.
Copyright Year	1983
Description	Journal: Drug Development and Industrial Pharmacy Dissolution rate and particle size distribution of griseofulvin were determined after simple blending or solvent deposition using colloidal silicon dioxide. Griseofulvin deaggregation in simple blends and micro-particulate drug dispersion in solvent deposited samples, both determinants of drug dissolution rate, were a function of silicon dioxide content. Solvent deposited samples scored impressively highly initial dissolution rates compared to corresponding simple blends. However, dissolution data thereafter were not encouraging. Drug particle size enlargment in griseofulvin rich samples and incomplete drug recovery from silicon dioxide rich samples were notable drawbacks in solvent deposition systems. Viscosity effects of silicon dioxide dispersion on griseofulvin dissolution were demonstrated. Simple blending with silicon dioxide was recommended as a means of promoting dissolution rate of griseofulvin. Limitation of average particle size data determined by methods which do not discriminate between drug and insoluble carrier is discussed.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639048309039888
Ending Page	808
Page Count	14
Starting Page	795
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639048309039888
Journal	Drug Development and Industrial Pharmacy
Issue Number	5
Volume Number	9
Language	English
Publisher	Informa UK Limited
Publisher Date	1983-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Silicon Dioxide Dioxide Tripurations Dispersion Method Grisgofulvin Silicon Particle Size
Content Type	Text
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effect of Particle Size on the Dissolution Rate of Monophenylbutazone Solid Dispersion in Presence of Certain Additives

Solid Dispersion Controlled Release: Effect of Particle Size, Compression Force and Temperature

Light-Scattering Method in Particle Size Analysis of Parenteral Emulsions

Dissolution Profiles of Ceftizoxime Suppository

Dissolution Characteristics of Interactive Powder Mixtures. Part One: Effect of Solubility and Particle Size of Excipients

Influence of Montmorillonite on the Dissolution and Bioavailablity of Phenyton

Dissolution from ordered mixtures: The effect of stirring rate and particle characteristics on the dissolution rate.

Effect of Granulating Method on Dissolution Rate of Compressed Tablets. III

Influence of Hydroxypropyl β-Cyclodextrin on Solubility and Dissolution Profile of Ketoprofen in Its Solid Dispersions

Influence of dispersion method on particle size and dissolution of grisgofulvin-silicon dioxide tripurations

Similar Documents

Effect of Particle Size on the Dissolution Rate of Monophenylbutazone Solid Dispersion in Presence of Certain Additives

Solid Dispersion Controlled Release: Effect of Particle Size, Compression Force and Temperature

Light-Scattering Method in Particle Size Analysis of Parenteral Emulsions

Dissolution Profiles of Ceftizoxime Suppository

Dissolution Characteristics of Interactive Powder Mixtures. Part One: Effect of Solubility and Particle Size of Excipients

Influence of Montmorillonite on the Dissolution and Bioavailablity of Phenyton

Dissolution from ordered mixtures: The effect of stirring rate and particle characteristics on the dissolution rate.

Effect of Granulating Method on Dissolution Rate of Compressed Tablets. III

Influence of Hydroxypropyl β-Cyclodextrin on Solubility and Dissolution Profile of Ketoprofen in Its Solid Dispersions

Influence of dispersion method on particle size and dissolution of grisgofulvin-silicon dioxide tripurations