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The Influence of Disintegrant Level and Capsule Size on Dissolution of Hard Gelatin Capsules Stored in High Humidity Conditions
| Content Provider | Scilit |
|---|---|
| Author | Dahl, T. C. Sue, I. T. Yum, A. |
| Copyright Year | 1991 |
| Description | Journal: Drug Development and Industrial Pharmacy Six batches of hard gelatin capsules were manufactured to explore the effect of disintegrant level and capsule fill porosity on the dissolution behavior of encapsulated dosage forms after exposure to high humidity. Size 0 capsules filled with powder blends containing 10 and 25% disintegrant dissolved faster than size 2 capsules filled with identical powder blends after storage under direct high humidity exposure. Interestingly, the trend was reversed when these identical products were exposed to high humidity but stored in, and protected by, a high density bottle-polypropylene container/closure system. It is hypothesized that capsules filled with a highly compacted powder blend, which are directly exposed to high humidity form a water layer at the gelatin-powder blend interface that inactivates the disintegrant. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03639049109040835 |
| Ending Page | 1016 |
| Page Count | 16 |
| Starting Page | 1001 |
| ISSN | 03639045 |
| e-ISSN | 15205762 |
| DOI | 10.3109/03639049109040835 |
| Journal | Drug Development and Industrial Pharmacy |
| Issue Number | 7 |
| Volume Number | 17 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Development and Industrial Pharmacy Legal Medicine Disintegrant Level Humidity Conditions Capsules Stored Capsule Size Hard Gelatin High Humidity Gelatin Capsules |
| Content Type | Text |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
