NDLI: Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1

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Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1

Content Provider	Scilit
Author	Chen, Lu Shan, Yu Zhang, Hengshuo Wang, Hongliang Chen, Yunzhen
Copyright Year	2020
Description	Objective: Circular RNA is a newly discovered non-coding RNA. It plays an important role in regulating gene expression, and may take part in tumor progression. This study aimed to investigate the functions of hsa_circ_0008792 in osteosarcoma regulation. Methods: We identified a circular RNA, hsa_circ_0008792, by using bioinformatics to analyze the GSE96962 dataset. The capacities of migration and invasion were assessed by wound-healing assay and transwell Matrigel assay. The ratios of G0/G1, S, and G2/M phases in cell cycle and apoptosis were measured using flow cytometry. Results: Hsa_circ_0008792 is expressed at low levels in osteosarcoma cells, and up-regulation of hsa_circ_0008792 could suppress osteosarcoma cell migration and invasion and promote apoptosis. This regulation is mediated by hsa-miR-711/ZFP1. The expression level of hsa_circ_0008792 showed no influence on cell cycle of osteosarcoma cells. Conclusion: Osteosarcoma is suppressed by hsa_circ_0008792/hsa-miR-711/ZFP1 axis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073447/pdf https://www.dovepress.com/getfile.php?fileID=56729
Ending Page	2181
Page Count	9
Starting Page	2173
ISSN	11786930
DOI	10.2147/ott.s239256
Journal	OncoTargets and therapy
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-03-01
Access Restriction	Open
Subject Keyword	Journal: Oncotargets and Therapy Integrative and Complementary Medicine Zfp1 Cerna Network Circular Rna Microrna Osteosarcoma
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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