NDLI: MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129

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MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129

Content Provider	Scilit
Author	Liu, Kai Zhang, Yingang Liu, Liang Yuan, Qiling
Copyright Year	2018
Description	MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129 Kai Liu, Yingang Zhang, Liang Liu, Qiling Yuan Department of Orthopedics, The First Affliated Hospital of Xi'an Jiaotong University, Xi'an, China Purpose: This article aimed to investigate the mechanism by which MALAT1 and miR-129 affected the development of osteosarcoma.Methods: Tumor tissues and adjacent tissues of 23 osteosarcoma patients were collected. Normal osteoblasts hFOB1.19 and osteosarcoma cells MG63 were cultured. MG63 cells were transfected and grouped: si-negative control (NC) group, si-MALAT1 group, miR-129 NC group, miR-129 mimics group, p-Empty vector group, p-MALAT1 group, p-MALAT1+ miR-129 mimics group, and p-MALAT1+ si-TGIF2 group. Luciferase reporter assay, Cell Counting Kit-8 assay, Transwell assay, quantitative reverse transcription PCR, Western blot, and Pearson correlation analysis were performed.Results: MALAT1 expression in tumor tissues and MG63 cells was increased (P
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287664/pdf https://www.dovepress.com/getfile.php?fileID=46712
Ending Page	8740
Page Count	12
Starting Page	8729
ISSN	11786930
DOI	10.2147/ott.s182993
Journal	OncoTargets and therapy
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-12-01
Access Restriction	Open
Subject Keyword	Journal: Oncotargets and Therapy Integrative and Complementary Medicine Oncology Malat1 Mir-129 Tgif2 Osteosarcoma Invasion Prognosis
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129

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MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129

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