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Inactivating Cdc25, Mitotic Style
| Content Provider | Scilit |
|---|---|
| Author | Wolfe, Benjamin A. Gould, Kathleen L. |
| Copyright Year | 2004 |
| Description | Mitotic entry and exit require activation and inactivation of the Cdk1-cyclin B kinase complex, respectively. The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups. Cdc25 family members, held inactive during interphase, are activated during mitotic progression in an amplification loop involving Cdk1-cyclin B. While Cdc25 activation at the G2/M transition is required for the timely initiation of mitosis, recent evidence suggests that the inactivation of Cdc25 in late mitosis may play a role in supporting Cdk1-cyclin B inactivation. Here, we discuss the mechanisms of Cdc25 regulation and how they pertain to both mitotic entry and exit. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.3.5.891?needAccess=true |
| Ending Page | 601 |
| Page Count | 3 |
| Starting Page | 599 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.3.5.891 |
| Journal | Cell Cycle |
| Issue Number | 5 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2004-05-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Developmental Biology Mitotic Inactivation of Cdc25 Inactivation of the Cdk1 Cyclin Mitosis Protein |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
