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Cdk1: Unsung Hero of S Phase?
| Content Provider | Scilit |
|---|---|
| Author | Pacek, Marcin Prokhorova, Tanya A. Walter, Johannes |
| Copyright Year | 2004 |
| Description | Cdk2 has been viewed as a key cell cycle regulator that is essential for S phase progression. The recent discovery that Cdk2 is not required for cell proliferation in mice now shows that other factors must be able to replace Cdk2 in stimulating DNA replication. Experiments performed in Xenopus egg extracts identify the mitotic protein kinases Cdk1/Cyclin B and Cdk1/Cyclin A as likely candidates. These observations raise the intriguing possibility that Cdk1 normally participates in genome duplication in wild type cells. |
| Related Links | https://www.landesbioscience.com/journals/cc/pacekCC3-4.pdf |
| Ending Page | 401 |
| Page Count | 3 |
| Starting Page | 399 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.3.4.776 |
| Journal | Cell Cycle |
| Issue Number | 4 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2004-04-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Developmental Biology Cdk2 Cdk1/cyclin Protein Kinases Duplication Mitotic Stimulating Intriguing Unsung |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |