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Mitotic Entry: A Matter of Oscillating Destruction
| Content Provider | Scilit |
|---|---|
| Author | Bassermann, Florian Peschel, Christian Duyster, Justus |
| Copyright Year | 2005 |
| Description | Entry into mitosis is essentially driven by cyclin B1 and its associated catalytically active partner Cdk1. While cyclin B1 is kept cytoplasmic throughout interphase, nuclear accumulation occurs just prior to mitosis. This restriction is thought to be part of an oscillating mechanism to properly time mitotic entry. A novel nuclear SCF-type mammalian E3 ligase defined by the F-box containing protein NIPA (nuclear interaction partner of ALK), SCFNIPA, targets nuclear cyclin B1 in interphase while it allows for accumulation at G2/M. Thus, oscillating ubiquitination of nuclear cyclin B1 driven by the SCFNIPA complex contributes to the timing of mitotic entry in the mammalian cell cycle. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.4.11.2192?needAccess=true https://www.landesbioscience.com/journals/cc/bassermannCC4-11.pdf |
| Ending Page | 1517 |
| Page Count | 3 |
| Starting Page | 1515 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.4.11.2192 |
| Journal | Cell Cycle |
| Issue Number | 11 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2005-08-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Cell Biology Developmental Biology Protein Mitosis Mitotic Oscillating Scfnipa Cyclin B1 Driven |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
