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Expression of Intercellular Adhesion Molecule 1 (Icam-1) on Human Articular Cartilage Chondrocytes
| Content Provider | Scilit |
|---|---|
| Author | Davies, M. Elisabeth Dingle, John T. Pigott, Rod Power, Christine Sharma, Harsh |
| Copyright Year | 1991 |
| Description | Monoclonal antibodies have been used to demonstrate the induction of intercellular adhesion molecule 1 (ICAM-1) on chondrocytes in human articular cartilage. ICAM-1 was found not to be constitutively expressed but could be induced by exogenous interleukin 1 alpha(IL1- alpha) at concentrations ranging from 0.01 to 20 ng/ml during in vitro culture. Maximum expression was observed with 2-5ng/ml. In time-course experiments ICAM-1 was not expressed after 4h in culture with IL1 alpha. Expression was induced by 16h and was sustained for a minimum of 6 days in the continued presence of the cytokine. The endothelial leukocyte adhesion molecule (ELAM-1) was not expressed on chondrocytes and was not induced by IL1-alpha. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/03008209109152439 |
| Ending Page | 216 |
| Page Count | 10 |
| Starting Page | 207 |
| ISSN | 03008207 |
| e-ISSN | 16078438 |
| DOI | 10.3109/03008209109152439 |
| Journal | Connective tissue research |
| Issue Number | 3 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Connective Tissue Research Cell Tissue Engineering Antibodies Articular Intercellular Cartilage Icam Adhesion Molecule Chondrocytes Induction 5ng/ml |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Cell Biology Molecular Biology Biochemistry Rheumatology |
