NDLI: Phosphorylation of Proteoglycans in Human Articular Cartilage

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Phosphorylation of Proteoglycans in Human Articular Cartilage

Content Provider	Scilit
Author	Schwartz, Edith R. Miller, Kathryn
Copyright Year	1978
Description	Journal: Connective tissue research A study of human articular cartilage indicated that componenet proteoglycans can be phosphorylated. Phosphorylation, also found in a specimen of human epiphysial cartilage, occurred when [gamma-32P]-ATP or 32Pi was included in the in vitro incubation medium. Treatment of the phosphorylated proteoglycans with chondroitinase and chondrosulfatases effectively removed the chondroitin sulfate without dephosphorylating the remaining molecule. Since phosphorylation could be effected in a totally chemically defined medium, it appears that the necessary enzyme systems for this reaction are contained entirely within chondrocytes.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03008207809152277
Ending Page	235
Page Count	11
Starting Page	225
ISSN	03008207
e-ISSN	16078438
DOI	10.3109/03008207809152277
Journal	Connective tissue research
Issue Number	4
Volume Number	5
Language	English
Publisher	Informa UK Limited
Publisher Date	1978-01-01
Access Restriction	Open
Subject Keyword	Journal: Connective tissue research Cell Tissue Engineering Phosphorylation Proteoglycans Articular Cartilage Human Articular
Content Type	Text
Subject	Orthopedics and Sports Medicine Cell Biology Molecular Biology Biochemistry Rheumatology

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