NDLI: Isolation and Chemical Analysis of a Fatty Acid Fraction of Kalanchoe pinnata with a Potent Lymphocyte Suppressive Activity

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Isolation and Chemical Analysis of a Fatty Acid Fraction of Kalanchoe pinnata with a Potent Lymphocyte Suppressive Activity

Content Provider	Scilit
Author	Rossi-Bergmann, B.
Editor	Almeida, A. P. Silva, S. A. G. Da Souza, M. L. M. Lima, L. M. T. R. R. de Moraes, V. L. Gonçalves Costa, S. S.
Copyright Year	2000
Description	Previously we demonstrated that Kalanchoe pinnata (KP) leaf extracts inhibited in vitro lymphocyte proliferation and showed in vivo immunosuppressive activity. Here we attempt to identify the immunosuppressive substances present in KP guided by the lymphoproliferative assays. From the ethanolic extract was purified a fraction (KP12SA) twenty-fold more potent to block murine lymphocyte proliferation than the crude extract. Chemical analysis by$ ^{1}$H- and$ ^{13}$C-NMR, IR and GC-MS of KP12SA (methylated sample) showed 89.3 % of palmitic acid $(C_{16}$), 10.7 % of stearic acid $(C_{18}$) and traces of arachidic $(C_{20}$) and behenic acids $(C_{22}$). This study provides evidence that fatty acids present in Kalanchoe pinnata may be responsible, at least in part, for its immunosuppressive effect in vivo.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2000-11131.pdf
Ending Page	137
Page Count	4
Starting Page	134
ISSN	00320943
e-ISSN	14390221
DOI	10.1055/s-2000-11131
Journal	Planta Medica
Issue Number	2
Volume Number	66
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2000-03-01
Access Restriction	Open
Subject Keyword	Journal: Planta Medica Integrative and Complementary Medicine Kalanchoe Pinnata Ethanolic Extract Saturated Fatty Acid Lymphocyte Proliferation
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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