Loading...
Please wait, while we are loading the content...
Similar Documents
Ginsenosides from Panax ginseng Differentially Regulate Lymphocyte Proliferation
| Content Provider | Scilit |
|---|---|
| Author | Cho, Jae Youl Kim, Ae Ra Yoo, Eun Sook Baik, Kyong Up Park, Myung Hwan |
| Copyright Year | 2002 |
| Description | We have examined the immunosuppressive effects of representative ginsenosides $(Rb_{1}$, $Rb_{2}$, Re and $Rg_{1}$) from Panax ginseng C. A. Meyer on CD4+ and CD8+ lymphocyte proliferation. Ginsenosides differentially modulated lymphocyte proliferation induced by concanavalin A (Con A), lipopolysaccharide (LPS), phytohemaglutinin (PHA) and interleukin-2 (IL-2). Thus, $Rb_{1}$ and Re significantly enhanced Con A-induced lymphocyte proliferation, whereas $Rg_{1}$ did not affect the proliferation. Interestingly, however, $Rb_{2}$ strongly blocked Con A, LPS and PHA-induced lymphocyte proliferation with the $IC_{50}$ values of 21.8, 29.0 and 24.0 μM, respectively. Moreover, $Rb_{2}$ inhibited Con A-stimulated IL-2 production with an $IC_{50}$ of 13.3 μM. In the IL-2-stimulated CD8+ T cell (CTLL-2) proliferation assay, Re and $Rg_{1}$ showed strong suppressive effects with $IC_{50}$ values of 57.5 and 64.7 μM, respectively. In contrast, neither $Rb_{1}$ nor $Rb_{2}$ did inhibit CTLL-2 cell proliferation at tested concentrations. These results suggest that ginsenosides from P. ginseng may modulate lymphocyte proliferation in a different manner. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2002-32556.pdf |
| Ending Page | 500 |
| Page Count | 4 |
| Starting Page | 497 |
| ISSN | 00320943 |
| e-ISSN | 14390221 |
| DOI | 10.1055/s-2002-32556 |
| Journal | Planta Medica |
| Issue Number | 6 |
| Volume Number | 68 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 2002-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Planta Medica Integrative and Complementary Medicine Lymphocyte Proliferation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science |
