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Streptozotocin Diabetes in Spontaneously Hypertensive Rats
| Content Provider | Scilit |
|---|---|
| Author | Voss, Christel Moritz, Vera Hartmann, K. Herrmann, Irene Zühlke, H. |
| Editor | von Dorsche, H. Hahn |
| Copyright Year | 1989 |
| Description | The aim of our experiments was to find out to what extent male spontaneously hypertensive (SH) as well as normotensive Wistar-Kyoto (WKY) and Wistar-Schönerlinde (WS) rats developed changes of the endocrine pancreas function in response to streptozotocin (SR). 4 week old WS, WKY and SH rats were given ip. injections of 70 or 100 mg SR/kg and were killed at an age of 8 weeks, after which blood glucose, and in isolated islets, insulin-leakage, insulin secretion and insulin biosynthesis were determined ; histologically the relative volume density of islet tissue was estimated. The results demonstrate that the intensity of the SR-caused damage to the endocrine pancreas differs considerably in the three strains of rats. The damage increases in the order WS, WKY, SH rats. These findings are indicative of the role played by genetic predisposition and of an increase in damage to the endocrine pancreas due to hypertension. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1210862.pdf |
| Ending Page | 240 |
| Page Count | 10 |
| Starting Page | 231 |
| ISSN | 09477349 |
| e-ISSN | 14393646 |
| DOI | 10.1055/s-0029-1210862 |
| Journal | Experimental and Clinical Endocrinology & Diabetes |
| Issue Number | 02/03 |
| Volume Number | 93 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1989-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental and Clinical Endocrinology & Diabetes Endocrinology and Metabolism Key Wordsdiabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
