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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Sanada, Luciana Sayuri Tavares, Marcelo Rodrigo Sato, Karina Laurenti Ferreira, Renata da Silva Neubern, Milena Cardoso Maia Castania, Jaci Ayrton Salgado, Helio Cesar Fazan, Valéria Paula Sassoli |
| Abstract | Background Prospective studies have shown incidence rates of hypertension in diabetes mellitus to be three times that of subjects without diabetes mellitus. The reverse also applies, with the incidence of diabetes two to three times higher in patients with hypertension. Despite this common clinical association, the contribution of each isolated entity in the development of a neuropathy is still not well understood. The aims of the present study were to investigate the presence of peripheral neuropathy in spontaneously hypertensive rats (SHR) and SHR with chronically induced diabetes, using a morphological and morphometric study of the sural nerves. Methods Female SHR and normotensive Wistar rats (WR), 8 weeks old, received a single intravenous injection of streptozotocin (STZ) through the tail vein. Controls from both strains received vehicle. Twelve weeks after the injection, sural nerves were dissected and prepared for light microscopy. Morphometry of sural nerve fascicles and myelinated fibers was performed with the aid of computer software. Results The sural nerve myelinated fibers were highly affected by experimental diabetes in normotensive rats, causing mainly the reduction of the fiber size. Hypertensive rats showed characteristics of small fiber neuropathy and a severe reduction of the number and density or Schwann cells. The association between diabetes and hypertension caused an increase on the average size of the myelinated fibers, pointing to a small fiber loss, associated to axonal atrophy. Conclusions Our study gives morphological support to the existence of a neuropathy due to hypertension, which is among one of the most common risk factors for diabetic neuropathy. The association between the two neuropathies showed to be a complex alteration, involving and including both, large and small fibers neuropathy. Hypertension caused, indeed, an exacerbation of the alterations already observed in experimental models of diabetic neuropathy. |
| Related Links | https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-015-0005-8.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17585996 |
| DOI | 10.1186/s13098-015-0005-8 |
| Journal | Diabetology & Metabolic Syndrome |
| Issue Number | 1 |
| Volume Number | 7 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-02-15 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Metabolic Diseases Endocrinology Sural nerve Myelinated fibers Morphometry Experimental hypertension Experimental diabetes Spontaneously hypertensive rats Streptozotocin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine |
| Journal Impact Factor | 3.4/2023 |
| 5-Year Journal Impact Factor | 4.1/2023 |
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