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Reduced Ability of Neutrophils to Produce Active Oxygen Species in Streptozotocin-Induced Diabetic Rats
| Content Provider | Scilit |
|---|---|
| Author | Sato, N. Shimizu, H. Shimomura, Y. Uehara, Y. Takahashi, M. Kobayashi, I. |
| Copyright Year | 1992 |
| Description | We investigated a possible alteration in the ability of neutrophils to produce active oxygen species in streptozotocin (STZ)-induced diabetic rats. The production of Superoxide of the neutrophils was assessed by luminol-dependent chemiluminescence (LDCL) after the stimulation by opsonized zymosan. Four days after STZ (60 mg/kg, ip) injection, blood glucose level increased by 399 ± 9 mg/dl and the LDCL activity was significantly reduced in diabetic rats (control group: 5.12±1.53 $KC/min^{2}/10^{6}$ cells, STZ group: 1.10±0.07 KC/ $min^{2}/10^{6}$ cells, p<0.01). At Day 17, blood glucose level was maintained high (598 ±8 mg/dl) and the LDCL activity (1.01 ± 0.39 $KC/min^{2}/10^{6}$ cells) was almost at the same level as that of diabetic rats at Day 4. Subcutaneous injection of insulin for 10 consecutive days increased the LDCL activity of diabetic rats in a dose-dependent manner (vehicle: 0.82±0.27 KC/ $min^{2}/10^{6}$ cells, 0.04 U/day: 1.61 ±0.09 $KC/min^{2}/10^{6}$ cells, 0.40 U/day: 1.99±0.47 $KC/min^{2}/10^{6}$ cells, 4.00 U/day: 3.33 ±0.43 $KC/min^{2}/10^{6}$ cells). The data obtained herein indicate that an increased susceptibility to bacterial infection in diabetic rats results from impaired neutrophil function to produce active oxygen species. |
| Related Links | http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1211128.pdf |
| Ending Page | 33 |
| Page Count | 3 |
| Starting Page | 31 |
| ISSN | 09477349 |
| e-ISSN | 14393646 |
| DOI | 10.1055/s-0029-1211128 |
| Journal | Experimental and Clinical Endocrinology & Diabetes |
| Issue Number | 01 |
| Volume Number | 99 |
| Language | English |
| Publisher | Georg Thieme Verlag KG |
| Publisher Date | 1992-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Experimental and Clinical Endocrinology & Diabetes Endocrinology and Metabolism Chemiluminescence Diabetes Mellitus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
