NDLI: Synthesis and Biological Activity of Some New Diarylsulphides and Diarylsulphones Containing Amino Acid Moieties, Part I

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Synthesis and Biological Activity of Some New Diarylsulphides and Diarylsulphones Containing Amino Acid Moieties, Part I

Content Provider	Scilit
Author	Abbady, M. A. Kandeel, M. M.
Copyright Year	1979
Abstract	4' -Nitro -4-aminodipheny lsulphide (1a) and/or 2'-nitro-4-amino-diphenylsulphide (1b) react with chloroacetylchloride giving 4-chloroacetylamino-diarylsulphides (2a, b) which undergo facile reaction with different amines and hydrazine yielding the 4-glycylamino and 4-hydrazinoacetylaminodiphenylsulphides (3) and (5). Two moles of 2 react with one mole of piperazine and/or hydrazine to give 1,4-Bis(p-N-(p'-nitrodiphenylsulphido)(amino- carbonylmethylene)piperazino (4) and 1,2-Bis(p-N-(o'-nitro-diphenylsulphido)(aminocar- bonylmethylene)hydrazine (6). On condensation of 5 with aromatic aldehydes yielded new Schiff bases (7). Oxidation of 3, 4, 6 and 7 using H₂O₂/CH₃COOH mixtures furnished the corresponding diarylsulphones 8, 9, 10 and 11, respectively. The biological activity of some of the prepared compounds were screened against some strains of bacteria
Related Links	http://www.degruyter.com/downloadpdf/j/znb.1979.34.issue-8/znb-1979-0822/znb-1979-0822.xml
Ending Page	1153
Page Count	5
Starting Page	1149
ISSN	09320776
e-ISSN	18657117
DOI	10.1515/znb-1979-0822
Journal	Zeitschrift für Naturforschung B
Issue Number	8
Volume Number	34
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	1979-08-01
Access Restriction	Open
Subject Keyword	Zeitschrift Für Naturforschung B Organic Chemistry Diarylsulphones Diarylsulphides Biological Activity Bis Mole Nitrodiphenylsulphido Aminocar Condensation Journal: Zeitschrift für Naturforschung B, Issue- 4
Content Type	Text
Resource Type	Article
Subject	Chemistry

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