Synthesis and biological activities of new bis-indole derivatives via microwave irradiation

Content Provider	Scilit
Author	Halawa, Ahmed H. Bedair, Ahmed H. El-Agrody, Ahmed M. Eliwa, Essam M. Frese, Marcel Sewald, Norbert Shaaban, Mohamed
Copyright Year	2017
Abstract	Three new series of bis-indole derivatives were synthesized based on p-phenylenediamine (2–4, 5 and 6) and 4,4′-ethylenedianiline moieties (7–9) using facile and efficient condensation of three positional isomeric indole-carboxaldehyde derivatives (1a–c) with bifunctional amines upon microwave irradiation. The symmetric dimeric indole derivatives 2–4 as well as non-symmetric analogues 5 and 6 were obtained by in situ condensation of the respective positional 3-, 2- and 5-isomeric indole-carboxaldehydes with p-phenylenediamine, while compounds 7–9 resulted from respective condensation based on 4,4′-ethylenedianiline. Structures of the obtained compounds were deduced by advanced spectroscopic methods (1H NMR, 13C NMR and MS). In agar diffusion assay, derivative 6 showed moderate antibacterial activity against various Gram positive and negative bacteria, while derivative 7 displayed moderate activity against several Gram positive bacteria. However, in Resazurin assay employing the human cervix carcinoma cell line (KB-3-1), derivatives 2–9 turned out to be inactive.
Related Links	http://www.degruyter.com/downloadpdf/j/znb.2017.72.issue-9/znb-2017-0039/znb-2017-0039.xml
Ending Page	646
Page Count	8
Starting Page	639
ISSN	09320776
e-ISSN	18657117
DOI	10.1515/znb-2017-0039
Journal	Zeitschrift für Naturforschung B
Issue Number	9
Volume Number	72
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2017-09-26
Access Restriction	Open
Subject Keyword	Zeitschrift Für Naturforschung B Medicinal Chemistry Antibacterial Activity Bis-indole Derivatives Cytotoxicity Microwave Irradiation Journal: Zeitschrift für Naturforschung B, Vol- 72, Issue- 1
Content Type	Text
Resource Type	Article
Subject	Chemistry