Cold-Brewed Jasmine Tea Attenuates High-Fat Diet-Induced Obesity and Gut Microbial Dysbiosis.

Content Provider	Europe PMC
Author	Li, Ang Wang, Jin Zhang, Xuejiao Kou, Ruixin Chen, Mengshan Zhang, Bowei Liu, Jingmin Peng, Bo Zhang, Yan Wang, Shuo
Editor	Carbonero, Franck Gael
Copyright Year	2022
Abstract	Cold-brewed jasmine tea (CB-JT) is regarded to possess characteristic flavors and health benefits as a novel resource of functional tea beverages. To investigate the molecular mechanisms underlying CB-JT-mediated protective effects on obesity, we evaluated the serum biochemistry, histological condition, glucose tolerance, gene expression profile and intestinal microbial diversity in high-fat diet (HFD)-fed mice. Our results demonstrate that cold-brewed jasmine tea can significantly attenuate HFD-induced body weight gain, abnormal serum lipid levels, fat deposition, hepatic injury, inflammatory processes as well as metabolic endotoxemia. CB-JT also modified the microbial community composition in HFD-fed mice and altered the balance to one closely resembled that of the control group. The differential abundance of core microbes in obese mice was reversed by CB-JT treatment, including an increment in the abundance of Blautia, Mucispirillum, and Bilophila as well as a decrease in the abundance of Alloprevotella. CB-JT was proved to regulate the mRNA expression levels of lipid metabolism-related genes such as Leptin, Pgc1a Il6, and Il1b in the adipose tissue coupled with Cyp7a1, Lxra, Srebp1c, and Atgl in the liver. These findings indicate that cold-brewed jasmine tea might be served as a potential functional tea beverage to prevent obesity and gut microbiota dysbiosis.
Journal	Nutrients
Volume Number	14
PubMed Central reference number	PMC9784320
Issue Number	24
PubMed reference number	36558518
e-ISSN	20726643
DOI	10.3390/nu14245359
Language	English
Publisher	MDPI
Publisher Date	2022-12-16
Access Restriction	Open
Rights License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors.
Subject Keyword	cold brew jasmine tea high-fat diet obesity gut microbiota mice
Content Type	Text
Resource Type	Article
Subject	Food Science Nutrition and Dietetics