NDLI: Bcl-2 and Bcl-XL Can Differentially Block Chemotherapy-Induced Cell Death

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Bcl-2 and Bcl-XL Can Differentially Block Chemotherapy-Induced Cell Death

Content Provider	Scilit
Author	Simonian, Philip L. Grillot, Didier A. M. Nuñez, Gabriel
Copyright Year	1997
Description	Bcl-2 and its homologue Bcl-XL are expressed in a variety of tumors and their expression modulates the sensitivity of tumor cells to a wide spectrum of chemotherapeutic agents and γ-irradiation. In the present report, we generated clones of FL5.12 lymphoid cells with similar levels of Bcl-2 and Bcl-XL using the Flag epitope to determine if these survival proteins could provide equivalent protection when challenged with chemotherapy or γ-irradiation. Using four M-phase specific chemotherapeutic agents, Bcl-XL and Bcl-2 provided similar protection against vincristine and vinblastine whereas Bcl-XL afforded as much as 50% greater cell viability than Bcl-2 against etoposide and teniposide-induced cell death. In addition, Bcl-XL provided significantly greater cell viability than Bcl-2 against methotrexate, fluorouracil, and hydroxyurea, three S-phase specific agents. In apoptosis induced by γ-irradiation and cisplatin, two antitumor treatments that are cell-cycle phase-nonspecific agents, both Bcl-XL and Bcl-2 conferred similar protection against γ-irradiation, but Bcl-XL provided better protection than Bcl-2 against cisplatin. These results indicate that Bcl-XL and Bcl-2 confer a differential ability to protect against chemotherapy-induced cell death, which appears to be dependent on the molecular mechanism targeted by the drug rather than its cell-cycle phase specificity.
Related Links	https://ashpublications.org/blood/article-pdf/90/3/1208/236039/1208.pdf
Ending Page	1216
Page Count	9
Starting Page	1208
DOI	10.1182/blood.v90.3.1208.1208_1208_1216
Journal	Blood
Issue Number	3
Volume Number	90
Language	English
Publisher	American Society of Hematology
Publisher Date	1997-08-01
Access Restriction	Open
Subject Keyword	Oncology Cell Death Apoptosis Viability Differentially Bcl Xl Similar Protection Chemotherapy Induced Cell Journal: Blood (Vol- 70, Issue- 3)
Content Type	Text
Resource Type	Article

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