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A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation
| Content Provider | Scilit |
|---|---|
| Author | Lin, Ey Orlofsky, A. Wang, Hong-Gang Reed, Jc Prystowsky, Mb |
| Copyright Year | 1996 |
| Description | A1, a bcl-2 family member, has been identified as a hematopoietic- specific, early inducible gene. In this study it is shown that stable transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor cell line, 32D c13, leads to a retardation of IL-3 withdrawal- induced cell death similar to that observed with transfection of bcl-2. However, unlike bcl-2. A1 expression permits the accumulation of differentiated myeloid cells both before and after IL-3 withdrawal. Total cell accumulation, on the other hand, is considerably greater after IL-3 deprivation in the bcl-2 transfectant than in A1-expressing cells. Cells cotransfected with the two genes behave similarly to cells singly transfected with bcl-2, except that viability following IL-3 withdrawal is somewhat further enhanced. These results suggest that these two proteins have distinct roles that may be related to the divergent regulation of their expression during myeloid differentiation. |
| Related Links | https://ashpublications.org/blood/article-pdf/87/3/983/620402/983.pdf |
| Ending Page | 992 |
| Page Count | 10 |
| Starting Page | 983 |
| DOI | 10.1182/blood.v87.3.983.bloodjournal873983 |
| Journal | Blood |
| Issue Number | 3 |
| Volume Number | 87 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1996-02-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Differentiation Cell Death Survival Hematopoietic Viability Accumulation Member Myeloid Bcl Journal: Blood (Vol- 70, Issue- 3) |
| Content Type | Text |
| Resource Type | Article |
