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Rusty neutrophils in β-thalassemia: no traction!
| Content Provider | Scilit |
|---|---|
| Author | Gaines, Peter Halene, Stephanie |
| Copyright Year | 2017 |
| Description | In this issue of Blood, Siwaponanan et al provide a potential novel mechanism for the increased infections observed in patients with $β-thalassemia.^{1}$ The authors find that neutrophils in 6-month-old β-thalassemic mice $(Hbb^{th3/+}$) and in patients have overall lower baseline levels of the ets-family transcription factor PU.1, and in mice lack upregulated Pu.1 expression in response to bacterial infection. This aberrant Pu.1 expression in mouse $Hbb^{th3/+}$ neutrophils is accompanied by defects in chemotaxis, phagocytosis, and production of reactive oxygen species (ROS). |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/129/23/3046.full.pdf |
| Ending Page | 3047 |
| Page Count | 2 |
| Starting Page | 3046 |
| DOI | 10.1182/blood-2017-04-776393 |
| Journal | Blood |
| Issue Number | 23 |
| Volume Number | 129 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2017-06-08 |
| Access Restriction | Open |
| Subject Keyword | Hematology Transcription Factor Neutrophils Defects Pu.1 Thalassemia Old Thalassemic Siwaponanan Journal: Blood (Vol- 137, Issue- 23) |
| Content Type | Text |
| Resource Type | Article |
