NDLI: Tfr2 suppression benefits β-thalassemic erythropoiesis

Content Provider	Scilit
Author	Ginzburg, Yelena Z. Fleming, Robert E.
Copyright Year	2018
Description	Multiple studies in murine model systems of β-thalassemia have demonstrated that iron restriction improves the ineffective erythropoiesis characteristic of this $disorder,^{1}$ the mechanisms of which have not yet been fully elucidated. In this issue of Blood, Artuso et al demonstrate that erythroid knockout of transferrin receptor 2 (Tfr2) also improves hematologic parameters in β-thalassemic $mice.^{2}$ The authors invoke changes in erythropoietin (Epo) sensitivity rather than erythroid iron delivery per se as the underlying mechanism.
Related Links	https://ashpublications.org/blood/article-pdf/132/21/2215/1467773/blood876110.pdf
Ending Page	2216
Page Count	2
Starting Page	2215
DOI	10.1182/blood-2018-10-876110
Journal	Blood
Issue Number	21
Volume Number	132
Language	English
Publisher	American Society of Hematology
Publisher Date	2018-11-22
Access Restriction	Open
Subject Keyword	Hematology Model Iron Thalassemia Transferrin Erythropoiesis Epo Tfr2 Thalassemic Artuso Journal: Blood (Vol- 134, Issue- 21)
Content Type	Text
Resource Type	Article

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