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Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients
| Content Provider | Scilit |
|---|---|
| Author | Siwaponanan, Panjaree Siegers, Jurre Ynze Ghazali, Mohamad Fakhrur Razi Ng, Thian McColl, Bradley Ng, Garrett Zhen-Wei Sutton, Philip Wang, Nancy Ooi, Isabelle Thiengtavor, Chayada Fucharoen, Suthat Chaichompoo, Pornthip Svasti, Saovaros Wijburg, Odilia Vadolas, Jim |
| Copyright Year | 2017 |
| Description | Key Points Aberrant neutrophil maturation is associated with reduced effector functions in β-thalassemia. PU.1, the key regulator of terminal neutrophil maturation, is dysregulated in β-thalassemia. |
| Related Links | https://ashpublications.org/blood/article-pdf/129/23/3087/1400969/blood730135.pdf |
| Ending Page | 3099 |
| Page Count | 13 |
| Starting Page | 3087 |
| DOI | 10.1182/blood-2016-07-730135 |
| Journal | Blood |
| Issue Number | 23 |
| Volume Number | 129 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2017-06-08 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Functions Terminal Pu.1 Thalassemia Dysregulated Aberrant Neutrophil Maturation Journal: Blood (Vol- 137, Issue- 23) |
| Content Type | Text |
| Resource Type | Article |