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Chronic granulocytic leukemia: cytogenetic conversion of the bone marrow with cycle-specific chemotherapy
| Content Provider | Scilit |
|---|---|
| Author | Smalley, Rv Vogel, J. Huguley, Cm Jr Miller, D. |
| Copyright Year | 1977 |
| Description | Sixteen patients with Ph1-positive chronic granulocytic leukemic (CGL) were entered on a pulsing chemotherapy program consisting of cytosine arabinoside 100 mg/sq m/day X 5 and thioguanine 100 mq/sq m/day X 5 every 21 days in an attempt to convert the Ph1-positive marrow to a Ph1- negative state and thereby achieve a complete remission. Twelve patients had an adequate trail of drug treatment, and ten of these had adequate chromosome examinations. There were two “conversions,” one of which was maintained for 5+ mo, while the other was transient. The program was unacceptable, however, to most patients due to intolerable nausea and vomiting. Thus a prospective chemotherapeutic attempt to convert a Ph1-positive marrow without splenectomy has induced a conversion in two of ten patients. Other regimens which might induce less nausea and vomiting and a higher rate of conversions should be sought in future attempts to alter the invariably fatal outcome of CGL. |
| Related Links | https://ashpublications.org/blood/article-pdf/50/1/107/205061/107.pdf |
| Ending Page | 113 |
| Page Count | 7 |
| Starting Page | 107 |
| DOI | 10.1182/blood.v50.1.107.bloodjournal501107 |
| Journal | Blood |
| Issue Number | 1 |
| Volume Number | 50 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1977-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Chemotherapy Nausea Vomiting Conversions M/day Granulocytic Ph1 Positive Journal: Blood (Vol- 3, Issue- 1) |
| Content Type | Text |
| Resource Type | Article |
