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Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Barrett, Aj Horowitz, Mm Ash, Rc Atkinson, K. Gale, Rp Goldman, Jm Downey, Pj Henslee Herzig, Rh Speck, B. Zwaan, Fe |
| Copyright Year | 1992 |
| Description | Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remission more than 2 years after transplant. Two-year actuarial probabilities (95% confidence interval) of leukemia-free survival were 38% (23% to 55%) for 33 patients transplanted in first remission, 41% (23% to 61%) for 22 patients transplanted after relapse, and 25% (9% to 53%) for 12 patients failing to achieve remission with conventional chemotherapy. These data indicate that transplants are effective treatment for Ph1- positive ALL. |
| Related Links | https://ashpublications.org/blood/article-pdf/79/11/3067/222928/3067.pdf |
| Ending Page | 3070 |
| Page Count | 4 |
| Starting Page | 3067 |
| DOI | 10.1182/blood.v79.11.3067.bloodjournal79113067 |
| Journal | Blood |
| Issue Number | 11 |
| Volume Number | 79 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1992-06-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Bone Marrow Leukemia Ph1 Philadelphia Conventional Chemotherapy Lymphoblastic Marrow Transplantation Journal: Blood (Vol- 116, Issue- 11) |
| Content Type | Text |
| Resource Type | Article |
