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Significance of Ph1-negative marrow cells in Ph1-positive chronic granulocytic leukemia
| Content Provider | Scilit |
|---|---|
| Author | Sokal, Je |
| Copyright Year | 1980 |
| Description | Fifty-six of 195 Ph1-positive patients with chronic granulocytic leukemia were found to have Ph1-negative metaphases in marrow aspirates on one or more occasions. In 22 cases, Ph1-negative cells were found prior to initiation of antileukemic therapy. Five patients were in the blastic stage of the disease when Ph1-negative mitoses were seen. The finding of Ph1-negative cells appeared to be related principally to short duration of CGL and to administration of antileukemic therapy (conventional agents and doses, in most cases). Ph1-negative cells were usually not found more than 2 yr after the diagnosis of leukemia, but in a few cases, they were seen as long as 5–10 yr after diagnosis. Only a minority of metaphases analyzed were Ph1-negative, except in the case of 6 patients who transiently had 50% or more Ph1-negative cells after antileukemic therapy. The presence of Ph1-negative cells in marrow was not associated with any survival advantage in this series. |
| Related Links | https://ashpublications.org/blood/article-pdf/56/6/1072/583513/1072.pdf |
| Ending Page | 1076 |
| Page Count | 5 |
| Starting Page | 1072 |
| DOI | 10.1182/blood.v56.6.1072.1072 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 56 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1980-12-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Survival Leukemia Antileukemic Granulocytic Marrow Cells Ph1 Negative Cells Journal: Blood (Vol- 86, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
