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How I treat and manage strokes in sickle cell disease
| Content Provider | Scilit |
|---|---|
| Author | Kassim, Adetola A. Galadanci, Najibah A. Pruthi, Sumit DeBaun, Michael R. |
| Copyright Year | 2015 |
| Description | Neurologic complications are a major cause of morbidity and mortality in sickle cell disease (SCD). In children with sickle cell anemia, routine use of transcranial Doppler screening, coupled with regular blood transfusion therapy, has decreased the prevalence of overt stroke from ∼11% to 1%. Limited evidence is available to guide acute and chronic management of individuals with SCD and strokes. Current management strategies are based primarily on single arm clinical trials and observational studies, coupled with principles of neurology and hematology. Initial management of a focal neurologic deficit includes evaluation by a multidisciplinary team (a hematologist, neurologist, neuroradiologist, and transfusion medicine specialist); prompt neuro-imaging and an initial blood transfusion (simple followed immediately by an exchange transfusion or only exchange transfusion) is recommended if the hemoglobin is >4 gm/dL and |
| Related Links | http://www.bloodjournal.org/content/bloodjournal/125/22/3401.full.pdf |
| Ending Page | 3410 |
| Page Count | 10 |
| Starting Page | 3401 |
| DOI | 10.1182/blood-2014-09-551564 |
| Journal | Blood |
| Issue Number | 22 |
| Volume Number | 125 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 2015-05-28 |
| Access Restriction | Open |
| Subject Keyword | Hematology Sickle Cell Disease Cerebral Infarcts Therapy Acute Strokes Blood Transfusion Anemia Neurology Management of Strokes Journal: Blood (Vol- 135, Issue- 22) |
| Content Type | Text |
| Resource Type | Article |
